LINKAGE OF EARLY-ONSET FAMILIAL BREAST CANCER TO CHROMOSOME 17Q21 PDF

PDF | Human breast cancer is usually caused by genetic alterations of somatic cells of the breast, but occasionally, susceptibility to the disease is inherited. Abstract, Full, Pdf. Apr , 3, 0, 0. May , 4, 0, 1. Jun , 2, 0, 0. Jul , 19, 0, 2. Aug , 21, 0, 1. Sep , 47, 0, 0. Oct , , 0, Nov PubMed journal article Linkage of early-onset familial breast cancer to chromosome 17q2 were found in PRIME PubMed. Download Prime PubMed App to.

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National Center for Biotechnology InformationEarly-ondet. There is probably more than one gene for inherited breast cancer, but heterogeneity may not be due to age at disease onset. Inheritance of human breast cancer: Familial breast-ovarian cancer locus on chromosome 17qq Am J Hum Genet.

Author information Copyright and License information Disclaimer. Genetic epidemiology of breast cancer in Britain.

Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.

Estimating the power of linkage analysis in hereditary breast cancer. Linkage of early-onset familial breast cancer to chromosome 17q Genetic analysis of breast cancer in the cancer and steroid hormone study. If this correction is made, then later-onset families are much less informative; linkage heterogeneity based on age at onset is no longer significant; and for the sample of families as a whole, linkage is significant at a recombination fraction since demonstrated to be close to the correct local.

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Associated Data Supplementary Materials. A new statistical test for linkage heterogeneity. Strategies for multilocus linkage analysis in humans.

Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.

Support Center Support Center. Closing in on a breast cancer gene on chromosome 17q. Open in a separate window.

Please review our privacy policy. See Am J Hum Genet. The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. This article has been cited by other articles in PMC. Segregation and linkage analysis of nine Utah breast cancer pedigrees.

Abstract Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently likage among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease. However, for late-onset cases, the relative probability of sporadic rather than inherited disease is higher than previously suggested.

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Genetic epidemiology of breast cancer: Inheritance of proliferative breast disease in breast cancer kindreds. Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are familal older-onset families, suggesting that linkage is restricted to early-onset disease.

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